CH 5450

CH 5450 (Z-Ile-Glu-Pro-Phe-Ome) is a selective short peptide human cardiac chymase inhibitor. CH-5450 inhibits the action of rat MAB elastase 2 on substrate Ang I with an IC50 value of 49 µM and N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide with an IC50 value of 4.8 µM[1].

Product Specifications

CAS Number

[252557-97-4]

Product Name Alternative

Z-Ile-Glu-Pro-Phe-Ome

UNSPSC

12352209

Hazard Statement

H302, H315, H319, H335

Target

Proteasome

Type

Peptides

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Z-Ile-Glu-Pro-Phe-Ome.html

Purity

98.19

Solubility

DMSO : ≥ 43 mg/mL

Smiles

O=C(OC)[C@@H](NC([C@H]1N(C([C@@H](NC([C@@H](NC(OCC2=CC=CC=C2)=O)[C@@H](C)CC)=O)CCC(O)=O)=O)CCC1)=O)CC3=CC=CC=C3

Molecular Formula

C34H44N4O9

Molecular Weight

652.73

Precautions

H302, H315, H319, H335

References & Citations

[1]Carlos F Santos, et al. Kinetic characterization and inhibition of the rat MAB elastase-2, an angiotensin I-converting serine protease. Can J Physiol Pharmacol. 2002 Jan;80 (1) :42-7.