Eglin c (42-45) -methyl ester

<strong>Eglin c (42-45)-methyl ester</strong>_x000D_ <strong>Catalog number:</strong> B2019077_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 5 mg_x000D_ <strong>Molecular Weight or Concentration:</strong> 442.56 g/mol_x000D_ <strong>Supplied as:</strong> Powder_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> RT_x000D_ <strong>Keywords:</strong> Eglin c (42-45)-methyl ester_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Komiyama T, Fuller RS. Engineered eglin c variants inhibit yeast and human proprotein processing proteases, Kex2 and furin Biochemistry. 2000 Dec 12;39(49):15156-65._x000D_ 2: Siebeck M, Hoffmann H, Weipert J, Fritz H. Effect of the elastase inhibitor eglin C in porcine endotoxin shock Circ Shock. 1992 Mar;36(3):174-9._x000D_ 3: Komiyama T, VanderLugt B, Fugère M, Day R, Kaufman RJ, Fuller RS. Optimization of protease-inhibitor interactions by randomizing adventitious contacts Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8205-10._x000D_ 4: Electricwala A, Von Sicard NA, Sawyer RT, Atkinson T. Biochemical characterisation of a pancreatic elastase inhibitor from the leech Hirudinaria manillensis J Enzyme Inhib. 1992;6(4):293-302._x000D_ 5: Nakabayashi K, Tsuboi S, Fujimoto T, Okada Y, Nagamatsu Y, Yamamoto J. Amino acids and peptides. XXIX. Synthesis of peptide fragments related to active center of eglin c and studies on the relationship between their structure and their inhibitory activity against cathepsin G and alpha-chymotrypsin Chem Pharm Bull (Tokyo). 1990 Dec;38(12):3249-52._x000D_ 6: Carden DL, Korthuis RJ. Protease inhibition attenuates microvascular dysfunction in postischemic skeletal muscle Am J Physiol. 1996 Nov;271(5 Pt 2):H1947-52._x000D_ 7: Tsuboi S, Takeda M, Okada Y, Nagamatsu Y, Yamamoto J. Amino acids and peptides. XXX. Synthesis of eglin c (41-49) and eglin c (60-63) and examination of their inhibitory activity towards human leukocyte elastase, cathepsin G, porcine pancreatic elastase and alpha-chymotrypsin Chem Pharm Bull (Tokyo). 1991 Jan;39(1):184-6._x000D_ 8: Glusa E, Adam C. Endothelium-dependent relaxation induced by cathepsin G in porcine pulmonary arteries Br J Pharmacol. 2001 Jun;133(3):422-8._x000D_ 9: Snider GL, Stone PJ, Lucey EC, Breuer R, Calore JD, Seshadri T, Catanese A, Maschler R, Schnebli HP. Eglin-c, a polypeptide derived from the medicinal leech, prevents human neutrophil elastase-induced emphysema and bronchial secretory cell metaplasia in the hamster Am Rev Respir Dis. 1985 Dec;132(6):1155-61._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/18393447">10: Boyer JA, Lee AL. Monitoring aromatic picosecond to nanosecond dynamics in proteins via 13C relaxation: expanding perturbation mapping of the rigidifying core mutation, V54A, in eglin c Biochemistry. 2008 Apr 29;47(17):4876-86. </a>_x000D_ _x000D_ <strong>Products Related to Eglin c (42-45)-methyl ester can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>