Kaempferol 3-O-sophoroside

Kaempferol 3-O-sophoroside is an orally active derivative of Kaempferol. It exhibits anti-inflammatory, analgesic, and antidepressant effects. Kaempferol 3-O-sophoroside is an inhibitor of the cell surface receptor toll-like receptor (TLR) 2/4 for High mobility group box 1 (HMGB1), and it also exerts anti-inflammatory effects by blocking the activation of NF-κB expression and the production of TNF-α. Kaempferol 3-O-sophoroside promotes the production of brain-derived neurotrophic factor (BDNF) and enhances autophagy by binding to AMP-activated protein kinase (AMPK), thereby exerting antidepressant effects. Kaempferol 3-O-sophoroside holds promise for research in the fields of inflammation and neurodegenerative diseases[1][2][3][4].

[1]Kim TH, et al. Anti-inflammatory effects of kaempferol-3-O-sophoroside in human endothelial cells. Inflamm Res. 2012 Mar;61(3):217-24.|[2]Kim T H, et al. Inhibitory effects of kaempferol-3-O-sophoroside on HMGB1-mediated proinflammatory responses[J]. Food and chemical toxicology, 2012, 50(3-4): 1118-1123.|[3]Wang R, et al. Kaempferol‐3‐O‐sophoroside (PCS‐1) contributes to modulation of depressive‐like behaviour in C57BL/6J mice by activating AMPK[J]. British journal of pharmacology, 2024, 181(8): 1182-1202.|[4]Parveen Z, et al. Antiinflammatory and analgesic activities of Thesium chinense Turcz extracts and its major flavonoids, kaempferol and kaempferol-3-O-glucoside[J]. Yakugaku Zasshi, 2007, 127(8): 1275-1279.