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LDN-193665

LDN-193665 is a Tau kinase inhibitor with tauopathy-modifying activity. LDN-193665 inhibits Tau phosphorylation, improves tauopathy in animal models, reduces Sarkosyl-insoluble Tau, and restores memory. It may be necessary to simultaneously target multiple kinases to effectively inhibit tauopathies.

Product Specifications

CAS Number

1289638-16-9

UNSPSC

12352005

Target

Tau Protein

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/ldn-193665.html

Smiles

O=C(C1=C(N)N=C(NC2=CC=CN=C2)S1)C3=CC(F)=CC=C3

Molecular Formula

C15H11FN4OS

Molecular Weight

314.34

References & Citations

[1]Diaminothiazoles modify Tau phosphorylation and improve the tauopathy in mouse models

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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