NDB
NDB is a selective human FXRα (hFXRα) antagonist that is effective in modulating transcription of FXRα downstream genes. NDB can be used in anti-diabetes research[1].
Product Specifications
CAS Number
[1660153-08-1]
UNSPSC
12352005
Target
FXR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/ndb.html
Purity
98.36
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N(C1=CC=C(O)C(C(C)(C)C)=C1)CC2=CC=CC=C2)C3=C(Cl)C=C(N(C)C)C=C3Cl
Molecular Formula
C26H28Cl2N2O2
Molecular Weight
471.42
References & Citations
[1]Xing Xu, et al. Structural Basis for Small Molecule NDB (N-Benzyl-N- (3- (tert-butyl) -4-hydroxyphenyl) -2,6-dichloro-4- (dimethylamino) Benzamide) as a Selective Antagonist of Farnesoid X Receptor α (FXRα) in Stabilizing the Homodimerization of the Receptor. J Biol Chem. 2015 Aug 7;290 (32) :19888-99.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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