(S) - (-) -5-Fluorowillardiine (hydrochloride)
(S) - (-) -5-Fluorowillardiine hydrochloride is a potent and specific AMPAR agonist.
Product Specifications
CAS Number
1321546-70-6
Product Name Alternative
(5S) -Fluorowillardiine hydrochloride; (S) -5-Fluorowillardiine hydrochloride
UNSPSC
12352005
Target
IGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/_S_-_-_-5-Fluorowillardiine-hydrochloride.html
Concentration
10mM
Purity
99.03
Solubility
10 mM in DMSO|H2O : 6.67 mg/mL (ultrasonic)
Smiles
OC([C@@H](N)CN1C=C(F)C(NC1=O)=O)=O.[H]Cl
Molecular Formula
C7H9ClFN3O4
Molecular Weight
253.62
References & Citations
[1]Hawkinson JE, et al. Effects of thiocyanate and AMPA receptor ligands on (S) -5-fluorowillardiine, (S) -AMPA and (R, S) -AMPA binding. Eur J Pharmacol. 1997 Jun 25;329 (2-3) :213-21.|[2]Kessler M, et al. Use of [3H]fluorowillardiine to study properties of AMPA receptor allosteric modulators. Brain Res. 2006 Mar 3;1076 (1) :25-41.|[3]Rembach A, et al. Antisense peptide nucleic acid targeting GluR3 delays disease onset and progression in the SOD1 G93A mouse model of familial ALS. J Neurosci Res. 2004 Aug 15;77 (4) :573-82.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AMPA Receptor
Available Sizes
Frequently Asked Questions
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