(S) - (-) -5-Fluorowillardiine (hydrochloride)

(S) - (-) -5-Fluorowillardiine hydrochloride is a potent and specific AMPAR agonist.

Product Specifications

CAS Number

[1321546-70-6]

Product Name Alternative

(5S) -Fluorowillardiine hydrochloride; (S) -5-Fluorowillardiine hydrochloride

UNSPSC

12352005

Target

IGluR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/_S_-_-_-5-Fluorowillardiine-hydrochloride.html

Concentration

10mM

Purity

99.03

Solubility

10 mM in DMSO|H2O : 6.67 mg/mL (ultrasonic)

Smiles

OC([C@@H](N)CN1C=C(F)C(NC1=O)=O)=O.[H]Cl

Molecular Formula

C7H9ClFN3O4

Molecular Weight

253.62

References & Citations

[1]Hawkinson JE, et al. Effects of thiocyanate and AMPA receptor ligands on (S) -5-fluorowillardiine, (S) -AMPA and (R, S) -AMPA binding. Eur J Pharmacol. 1997 Jun 25;329 (2-3) :213-21.|[2]Kessler M, et al. Use of [3H]fluorowillardiine to study properties of AMPA receptor allosteric modulators. Brain Res. 2006 Mar 3;1076 (1) :25-41.|[3]Rembach A, et al. Antisense peptide nucleic acid targeting GluR3 delays disease onset and progression in the SOD1 G93A mouse model of familial ALS. J Neurosci Res. 2004 Aug 15;77 (4) :573-82.