Triflusal-d3

Triflusal-d3 is deuterium labeled Triflusal.

Product Specifications

CAS Number

[2748541-63-9]

UNSPSC

12352005

Target

COX; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Immunology/Inflammation; Others

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Solubility

10 mM in DMSO

Smiles

O=C(O)C1=CC=C(C(F)(F)F)C=C1OC(C([2H])([2H])[2H])=O

Molecular Formula

C10H4D3F3O4

Molecular Weight

251.17

References & Citations

[3]Duran, X., et al., Protective effects of triflusal on secondary thrombus growth and vascular cyclooxygenase-2. J Thromb Haemost, 2008. 6 (8) : p. 1385-92.|[4]Fernández de Arriba A, et al. Inhibition of cyclooxygenase-2 expression by 4-trifluoromethyl derivatives of salicylate, triflusal, and its deacetylated metabolite, 2-hydroxy-4-trifluoromethylbenzoic acid. Mol Pharmacol. 1999 Apr;55 (4) :753-60.|[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]De Miguel, L.S., et al., A 4-trifluoromethyl derivative of salicylate, triflusal, stimulates nitric oxide production by human neutrophils: role in platelet function. Eur J Clin Invest, 2000. 30 (9) : p. 811-7.