GSK2018682 (hydrochloride)
GSK2018682 hydrochloride is an agonist for S1P1 and S1P5 receptor with pEC50s of 7.7 and 7.2, respectively, and has no agonist activity towards human S1P2, S1P3, or S1P4. GSK2018682 hydrochloride is used in the research of multiple sclerosis.
Product Specifications
CAS Number
1034687-52-9
UNSPSC
12352005
Target
LPL Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/gsk2018682-hydrochloride.html
Smiles
O=C(CCCN1C=CC2=C(C3=NOC(C4=CC(Cl)=C(OC(C)C)N=C4)=N3)C=CC=C21)O.Cl
Molecular Formula
C22H22Cl2N4O4
Molecular Weight
477.34
References & Citations
[1]Xu J, et al. Safety, pharmacokinetics, pharmacodynamics, and bioavailability of GSK2018682, a sphingosine-1-phosphate receptor modulator, in healthy volunteers. Clin Pharmacol Drug Dev. 2014 May;3 (3) :170-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
Frequently Asked Questions
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