DS17
Product Specifications
UNSPSC Description
DS17 is a molecular glue that acts as a potent degrader of cyclin K, with an EC50 of 13 nM. DS17 plays an important role in cancer research[1].
Target Antigen
CDK; Molecular Glues
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ds17.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(C)N(C=N1)C2=C1C(NCC3=NC(C=C(Cl)C(Cl)=C4)=C4N3)=NC(N[C@H](CC)CO)=N2
Molecular Weight
463.36
References & Citations
[1]Zuzanna Kozicka, et al. Design principles for cyclin K molecular glue degraders. Nat Chem Zuzanna Kozicka, et al. Design principles for cyclin K molecular glue degraders. Nat Chem Biol. 2024 Jan;20(1):93-102. Biol. 2024 Jan;20(1):93-102.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-160501/DS17-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-160501/DS17-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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