DS17
DS17 is a molecular glue that acts as a potent degrader of cyclin K, with an EC50 of 13 nM. DS17 plays an important role in cancer research[1].
Product Specifications
UNSPSC
12352005
Target
CDK; Molecular Glues
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ds17.html
Purity
98.81
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(C)N(C=N1)C2=C1C(NCC3=NC(C=C(Cl)C(Cl)=C4)=C4N3)=NC(N[C@H](CC)CO)=N2
Molecular Formula
C20H24Cl2N8O
Molecular Weight
463.36
References & Citations
[1]Zuzanna Kozicka, et al. Design principles for cyclin K molecular glue degraders. Nat Chem Zuzanna Kozicka, et al. Design principles for cyclin K molecular glue degraders. Nat Chem Biol. 2024 Jan;20 (1) :93-102. Biol. 2024 Jan;20 (1) :93-102.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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