Dimethyl fumarate

Dimethyl fumarate (DMF) is an orally active and brain-penetrant Nrf2 activator and induces upregulation of antioxidant gene expression. Dimethyl fumarate induces necroptosis in colon cancer cells through GSH depletion/ROS increase/MAPKs activation pathway, and also induces cell autophagy. Dimethyl fumarate can be used for multiple sclerosis research[1][2].

Product Specifications

CAS Number

[624-49-7]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; Endogenous Metabolite; HIV; Keap1-Nrf2; Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Anti-infection; Autophagy; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Dimethyl-fumarate.html

Purity

99.99

Solubility

DMSO : 40 mg/mL (ultrasonic)

Smiles

O=C(OC)/C=C/C(OC)=O

Molecular Formula

C6H8O4

Molecular Weight

144.13

Precautions

H302, H315, H319, H335

References & Citations

[1]Peng H, et al. Dimethyl fumarate inhibits dendritic cell maturation via nuclear factor κB (NF-κB) and extracellular signal-regulated kinase 1 and 2 (ERK1/2) and mitogen stress-activated kinase 1 (MSK1) signaling. J Biol Chem. 2012 Aug 10;287 (33) :28017-26.|[2]Cross SA, et al. Dimethyl fumarate, an immune modulator and inducer of the antioxidant response, suppresses HIV replication and macrophage-mediated neurotoxicity: a novel candidate for HIV neuroprotection. J Immunol. 2011 Nov 15;187 (10) :5015-25.|[3]Jing X, et al. Dimethyl fumarate attenuates 6-OHDA-induced neurotoxicity in SH-SY5Y cells and in animal model of Parkinson's disease by enhancing Nrf2 activity. Neuroscience. 2015 Feb 12;286:131-40|[4]Xin Xie, et al. Dimethyl fumarate induces necroptosis in colon cancer cells through GSH depletion/ROS increase/MAPKs activation pathway. Br J Pharmacol. 2015 Aug;172 (15) :3929-43.