Ergtoxin-1
Ergtoxin-1 is a potassium channel blocker. Ergtoxin-1 is isolated from the venom of the Mexican scorpion Centruroides noxius. Ergtoxin 1 can block ERG-K+ channels in nerve, heart and endocrine cells[1].
Product Specifications
CAS Number
304436-85-9
Product Name Alternative
ErgTx1
UNSPSC
12352209
Target
Potassium Channel
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ergtoxin-1.html
Solubility
10 mM in DMSO
Smiles
O=C([C@@H](N)CC(O)=O)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]1CC(O)=O)=O)CCC(N)=O)=O)CSSC[C@H](NC2=O)C(N[C@H]3CCCCN)=O)=O)CCC(O)=O)=O)CCC(N)=O)=O)CC4=CC=C(O)C=C4)=O)CC5=CC=C(O)C=C5)=O)=O)CC6=CC=C(O)C=C6)=O)CCCCN)=O)C)=O)CSSC[C@H](NC7=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]2CCCCN)=O)CC8=CC=CC=C8)=O)CC9=CC=CC=C9)=O)CCSC)=O)=O)CCCNC(N)=N)=O)CO)=O)CCCCN)=O)CC(O)=O)=O)C(C)C)=O)CSSC[C@H](NC1=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(NCC(NCC(N[C@H]7[C@@H](C)O)=O)=O)=O)CC(N)=O)=O)CC%10=CNC=N%10)=O)=O)C)=O)CC(N)=O)=O)CCCCN)=O)CSSC[C@H](NC3=O)C(N[C@H](C(O)=O)C)=O)=O)=O)CO)=O)CC(O)=O)=O)CCCNC(N)=N
Molecular Formula
C193H287N59O63S9
Molecular Weight
4730.29
References & Citations
[1]Scaloni A, et al. Disulfide bridges of ergtoxin, a member of a new sub-family of peptide blockers of the ether-a-go-go-related K+ channel. FEBS Lett. 2000 Aug 18;479 (3) :156-7.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
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