ARC 239

ARC 239 is an α2B/C-adrenergic receptor antagonist with pKi of 7.06 and 6.95 for rat kidney α2B and human α2C, respectively. ARC 239 also inhibits 5-HT1A receptor with a Ki of 63.1 nM[1][2].

Product Specifications

CAS Number

[67339-62-2]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

5-HT Receptor; Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/arc-239.html

Purity

99.71

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C1N(CCN2CCN(C3=CC=CC=C3OC)CC2)C(C(C)(C)C4=C1C=CC=C4)=O

Molecular Formula

C24H29N3O3

Molecular Weight

407.51

Precautions

H302, H315, H319, H335

References & Citations

[1]K T Gavin, et al. Alpha 2C-adrenoceptors mediate contractile responses to noradrenaline in the human saphenous vein. Naunyn Schmiedebergs Arch Pharmacol. 1997 Mar;355 (3) :406-11. |[2]J J Meana, et al. The subtype-selective alpha 2-adrenoceptor antagonists BRL 44408 and ARC 239 also recognize 5-HT1A receptors in the rat brain. Eur J Pharmacol. 1996 Oct 3;312 (3) :385-8.