NNC-0640

NNC-0640 is an effective negative allosteric modulator (NAM) of the human glucagon receptor (GCGR), with an IC50 value of 69.2 nM. NNC-0640 holds potential for research in the field of diabetes[1].

Product Specifications

CAS Number

[307986-98-7]

UNSPSC

12352005

Hazard Statement

H228, H315, H319

Target

GCGR

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/nnc-0640.html

Purity

98.43

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(NC1=NN=NN1)C2=CC=C(CN(C3=CC=C(C4CCCCC4)C=C3)C(NC5=CC=CC(S(=O)(C)=O)=C5)=O)C=C2

Molecular Formula

C29H31N7O4S

Molecular Weight

573.67

Precautions

H228, H315, H319

References & Citations

[1]Zhang H, et al. Structure of the full-length glucagon class B G-protein-coupled receptor. Nature. 2017 Jun 8;546 (7657) :259-264.|[2]Song G, et al. Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators. Nature. 2017 Jun 8;546 (7657) :312-315.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

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