Bromocriptine

Bromocriptine is a potent dopamine D2/D3 receptor agonist, which binds D2 dopamine receptor with pKi of 8.05±0.2.

Product Specifications

CAS Number

[25614-03-3]

Product Name Alternative

CB-154 (free base)

UNSPSC

12352005

Hazard Statement

H301-H311-H331

Target

Dopamine Receptor

Type

Natural Products

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Bromocriptine.html

Solubility

10 mM in DMSO

Smiles

[H][C@@]12CC3=C(Br)NC4=CC=CC(C1=C[C@@H](C(N[C@@]5(C(C)C)C(N6[C@@H](CC(C)C)C(N7CCC[C@]7([C@]6(O)O5)[H])=O)=O)=O)CN2C)=C43

Molecular Formula

C32H40BrN5O5

Molecular Weight

654.59

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361-P403+P233-P405-P501

References & Citations

[1]Gardner B, et al. Agonist action at D2 (long) dopamine receptors: ligand binding and functional assays. Br J Pharmacol. 1998 Jul;124 (5) :978-84.|[2]Renodon A, et al. Bromocriptine is a strong inhibitor of brain nitric oxide synthase: possible consequences for the origin of its therapeutic effects.FEBS Lett. 1997 Apr 7;406 (1-2) :33-6.|[3]Wynalda MA, et al. Assessment of potential interactions between dopamine receptor agonists and various human cytochrome P450 enzymes using a simple in vitro inhibition screen. Drug Metab Dispos. 1997 Oct;25 (10) :1211-4.|[4]Rana DG, et al. Dopamine mediated antidepressant effect of Mucuna pruriens seeds in various experimental models of depression. Ayu. 2014 Jan;35 (1) :90-7.|[5]Dieb W, et al. Nigrostriatal dopaminergic depletion increases static orofacial allodynia. J Headache Pain. 2016;17:11.