Pamoic acid (Standard)

Pamoic acid (Standard) is the analytical standard of Pamoic acid. This product is intended for research and analytical applications. Pamoic acid (Embonic acid) is a potent GPR35 agonist with an EC50 of 79 nM. Pamoic acid exhibits neuroprotective and anti-inflammatory properties[1][2].

Product Specifications

CAS Number

[130-85-8]

Product Name Alternative

Embonic acid (Standard)

UNSPSC

12352005

Target

ERK; GPR35 ; Reference Standards

Type

Reference Standards

Related Pathways

GPCR/G Protein; MAPK/ERK Pathway; Others; Stem Cell/Wnt

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/pamoic-acid-standard.html

Smiles

OC1=C(C(O)=O)C=C2C(C=CC=C2)=C1CC3=C(O)C(C(O)=O)=CC4=C3C=CC=C4

Molecular Formula

C23H16O6

Molecular Weight

388.38

References & Citations

[1]Ozayra Sharmin, et al. Activation of GPR35 protects against cerebral ischemia by recruiting monocyte-derived macrophages. Sci Rep. 2020 Jun 10;10 (1) :9400. |[2]Pingwei Zhao, et al. Targeting of the orphan receptor GPR35 by pamoic acid: a potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activity. Mol Pharmacol. 2010 Oct;78 (4) :560-8.