PROTAC 20S proteasome subunit β5 degrader 1
Product Specifications
UNSPSC Description
PROTAC 20S proteasome subunit β5 degrader 1 (compound 12f) is a targeted degrader of PROTAC for 20S proteasome subunit β5, with a DC50 value of 0.11 μM in FaDu cells. PROTAC 20S proteasome subunit β5 degrader 1 disrupts the cell cycle, promotes apoptosis, and inhibits cell proliferation and migration in both FaDu and KM3/BTZ cells. PROTAC 20S proteasome subunit β5 degrader 1 can be used to study the resistance of pharyngeal cancer and multiple myeloma to Bortezomib (HY-10227) (Pink: Target protein ligand (HY-10227); Blue: E3 ligase ligand (HY-103596); Black: Linker (HY-169142))[1].
Target Antigen
Apoptosis; PROTACs
Type
Reference compound
Related Pathways
Apoptosis;PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-20s-proteasome-subunit-β5-degrader-1.html
Smiles
O=C1CCC(C(N1)=O)N2C(C3=C(C(OCC(NCCCCCCCNC(C4=CC=C(C=C4)C(N[C@@H](CC5=CC=CC=C5)C(N[C@H](B6O[C@@]7(C)[C@@H](C[C@H]8CC7O6)C8(C)C)CC(C)C)=O)=O)=O)=O)=CC=C3)C2=O)=O
Molecular Weight
986.95
References & Citations
[1]Wang S, et al. Discovery of novel 20S proteasome subunit β5 PROTAC degraders as potential therapeutics for pharyngeal carcinoma and Bortezomib-resistant multiple myeloma[J]. Bioorganic Chemistry, 2024: 107801.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-169134/PROTAC-20S-proteasome-subunit-β5-degrader-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-169134/
Clinical Information
No Development Reported
Curated Selection
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