11 ß-HSD1 Double Nickase Plasmid

<strong>11 ß-HSD1 Double Nickase Plasmid</strong>_x000D_ <strong>Catalog number:</strong> B2015204_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 10 ¬µg_x000D_ <strong>Molecular Weight or Concentration:</strong> N/A_x000D_ <strong>Supplied as:</strong> Powder_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> 2 - 8 ¬∞C_x000D_ <strong>Keywords:</strong> 11 ß-HSD1 Double Nickase Plasmid_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MŒ©-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Anagnostis P, Katsiki N, Adamidou F, Athyros VG, Karagiannis A, Kita M, Mikhailidis DP. 11beta-Hydroxysteroid dehydrogenase type 1 inhibitors: novel agents for the treatment of metabolic syndrome and obesity-related disorders? Metabolism. 2013 Jan;62(1):21-33._x000D_ 2: Li X, Wang J, Yang Q, Shao S. 11 ß-Hydroxysteroid Dehydrogenase Type 1 in Obese Subjects With Type 2 Diabetes Mellitus Am J Med Sci. 2017 Oct;354(4):408-414._x000D_ 3: Chapman KE, Gilmour JS, Coutinho AE, Savill JS, Seckl JR. 11Beta-hydroxysteroid dehydrogenase type 1--a role in inflammation? Mol Cell Endocrinol. 2006 Mar 27;248(1-2):3-8._x000D_ 4: Nixon M, Wake DJ, Livingstone DE, Stimson RH, Esteves CL, Seckl JR, Chapman KE, Andrew R, Walker BR. Salicylate downregulates 11 ß-HSD1 expression in adipose tissue in obese mice and in humans, mediating insulin sensitization Diabetes. 2012 Apr;61(4):790-6._x000D_ 5: St Jean DJ Jr, Wang M, Fotsch C. Inhibitors of 11beta-HSD1: a potential treatment for the metabolic syndrome Curr Top Med Chem. 2008;8(17):1508-23._x000D_ 6: DeSchoolmeester J, Palming J, Persson T, Pereira MJ, Wallerstedt E, Brown H, Gill D, Renstr√∂m F, Lundgren M, Svensson MK, Rees A, Eriksson JW. Differences between men and women in the regulation of adipose 11 ß-HSD1 and in its association with adiposity and insulin resistance Diabetes Obes Metab. 2013 Nov;15(11):1056-60._x000D_ 7: Morris DJ, Latif SA, Hardy MP, Brem AS. Endogenous inhibitors (GALFs) of 11beta-hydroxysteroid dehydrogenase isoforms 1 and 2: derivatives of adrenally produced corticosterone and cortisol J Steroid Biochem Mol Biol. 2007 May;104(3-5):161-8._x000D_ 8: Abrahams L, Semjonous NM, Guest P, Zielinska A, Hughes B, Lavery GG, Stewart PM. Biomarkers of hypothalamic-pituitary-adrenal axis activity in mice lacking 11 ß-HSD1 and H6PDH J Endocrinol. 2012 Sep;214(3):367-72._x000D_ 9: Davidson CT, Dover AR, McVicar CM, Megaw R, Glenn JV, Hadoke PWF, Stitt AW, Walker BR. Inhibition or deletion of 11 ß-HSD1 does not increase angiogenesis in ischemic retinopathy Diabetes Metab. 2017 Oct;43(5):480-483._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/23512810">10: Lee JH, Gao Z, Ye J. Regulation of 11 ß-HSD1 expression during adipose tissue expansion by hypoxia through different activities of NF-Œ∫B and HIF-1Œ± Am J Physiol Endocrinol Metab. 2013 May 15;304(10):E1035-41. </a>_x000D_ _x000D_ <strong>Products Related to 11 ß-HSD1 Double Nickase Plasmid can be found at</strong> <a href="https://moleculardepot.com/product-category/DNA/"> DNA</a>