Anti-Fibroblast Growth Factor 13 (FGF13) Antibody

Mouse Monoclonal Antibody specific to Fibroblast Growth Factor 13 (FGF13)

Product Specifications

CAS Number

9007-83-4

Product Name Alternative

FGF-13, Fibroblast growth factor homologous factor 2, FHF-2

Gene Name

FGF13

NCBI Gene ID

UniProt

Q92913

Cellular Locus

[Isoform 1]: Nucleus, Nucleus, Nucleus, Nucleus, Nucleus, Cell projection, growth cone, Cell projection, dendrite, Cell membrane, sarcolemma, Cytoplasm

Host

Mouse

Reactivity

Human, Mouse, Rat

Immunogen

Fusion protein corresponding to aa 2-18 (AAAIASSLIRQKRQARE) of human FGF13. This sequence is 100

Target Antigen

Fibroblast growth factor 13

Target

Fibroblast Growth Factor 13 (FGF13)

Clonality

Monoclonal

Isotype

IgG2b

Type

Antibody

Applications

WB, IHC, ICC/IF

Field of Research

Growth Factors, Cytokines, Receptors

Purification Method

Purified by Protein G affinity chromatography

Concentration

1.0 mg/mL

Dilution

Dilute in PBS or medium that is identical to that used in the assay system.

Format

Purified

Form

Liquid

Buffer

Phosphate Buffered Saline

Function

Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules (By similarity). Through its action on microtubules, may participate in the refinement of axons by negatively regulating axonal and leading processes branching (By similarity). Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus (By similarity). Regulates voltage-gated sodium channels transport and function (PubMed:15282281, PubMed:33245860). May also play a role in MAPK signaling (By similarity). Required for the development of axonal initial segment-targeting inhibitory GABAergic synapses made by chandelier neurons (By similarity). {UniProtKB:P70377, PubMed:15282281, PubMed:33245860}.

Additionnal Information

Immunoblotting: use at 1-5ug/mL. A band of ~30kDa is detected. Immunofluorescence: use at 10ug/mL. These are recommended concentrations. Endusers should determine optimal concentrations for their application.

Storage Conditions

This product is stable for at least one (1) year at -20°C.

Specificity

This antibody recognizes human, mouse, and rat FGF13.

Formulation

PBS, pH 7.4, 0.1% sodium azide, 50% glycerol.

Buffer pH

pH 7.4

Target Background

FGF13 (also known as FGF2 and FHF2) is a member of the fibroblast growth factor family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. The FGF13 gene is located in a region on chromosome X that is associated with Borjeson-Forssman-Lehmann syndrome (BFLS), making it a candidate gene for familial cases of BFLS and other syndromal and nonspecific forms of X-linked mental retardation mapping to this region. Alternative splicing of this gene at the 5â€² end results in several transcript variants encoding different isoforms with different N-termini.