Anti-Fibroblast Growth Factor 13 (FGF13) Antibody

[Isoform 1]: Nucleus, Nucleus, Nucleus, Nucleus, Nucleus, Cell projection, growth cone, Cell projection, dendrite, Cell membrane, sarcolemma, Cytoplasm

Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules (By similarity). Through its action on microtubules, may participate in the refinement of axons by negatively regulating axonal and leading processes branching (By similarity). Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus (By similarity). Regulates voltage-gated sodium channels transport and function (PubMed:15282281, PubMed:33245860). May also play a role in MAPK signaling (By similarity). Required for the development of axonal initial segment-targeting inhibitory GABAergic synapses made by chandelier neurons (By similarity). {UniProtKB:P70377, PubMed:15282281, PubMed:33245860}.

Immunoblotting: use at 1-5ug/mL. A band of ~30kDa is detected. <br><br>Immunofluorescence: use at 10ug/mL. <br><br>These are recommended concentrations. <br><br>Endusers should determine optimal concentrations for their application.

FGF13 (also known as FGF2 and FHF2) is a member of the fibroblast growth factor family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. The FGF13 gene is located in a region on chromosome X that is associated with Borjeson-Forssman-Lehmann syndrome (BFLS), making it a candidate gene for familial cases of BFLS and other syndromal and nonspecific forms of X-linked mental retardation mapping to this region. Alternative splicing of this gene at the 5′ end results in several transcript variants encoding different isoforms with different N-termini.