OT-551

OT-551 is a NF-κB inhibitor with antioxidant and anti-inflammatory effects. OT-551 has the potential for retinal diseases research[1][2].

Product Specifications

CAS Number

[627085-15-8]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

NF-κB

Type

Reference compound

Related Pathways

NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ot-551.html

Solubility

10 mM in DMSO

Smiles

CC1(C)CC(OC(C2CC2)=O)CC(C)(C)N1O.[H]Cl

Molecular Formula

C13H24ClNO3

Molecular Weight

277.79

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Masaki Tanito, et al. Protection of retinal pigment epithelium by OT-551 and its metabolite TEMPOL-H against light-induced damage in rats. Exp Eye Res. 2010 Jul;91 (1) :111-4. |[2]S. A. Mousa, et al. Anti-Angiogenesis Efficacy of the Novel NF-B and Oxidative Stress Inhibitor, OT-551. ARVO Annual Meeting Abstract.