DDO-2093 (dihydrochloride)
DDO-2093 dihydrochloride is a potent MLL1-WDR5 protein-protein interaction inhibitor (IC50=8.6 nM; Kd=11.6 nM) with antitumor activity. DDO-2093 dihydrochloride selectively inhibits the catalytic activity of MLL complex[1].
Product Specifications
UNSPSC
12352005
Target
WDR5
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ddo-2093-dihydrochloride.html
Concentration
10mM
Purity
98.79
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=CN(C2=CC=C(N3CCN(C)CC3)C(NC(C4=CC(N)=C(F)C(C)=C4Cl)=O)=C2)N=N1)NCCCN5CCOCC5.[H]Cl.[H]Cl
Molecular Formula
C29H39Cl3FN9O3
Molecular Weight
687.04
References & Citations
[1]Chen W, et al. Discovery of a potent MLL1 and WDR5 protein-protein interaction inhibitor with in vivo antitumor activity [published online ahead of print, 2021 Jun 28]. Eur J Med Chem. 2021;223:113677.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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