E3 ligase Ligand 24
E3 ligase Ligand 24 (Compound 24) is a Potent Ligand for the E3 Ligase DCAF15 (IC50= 0.053 μM) . Due to E3 ligase Ligand 24’s selectivity and potent binding characteristics, it is pivotal in the study of targeted protein degradation[1].
Product Specifications
CAS Number
3038773-47-3
UNSPSC
12352005
Target
Ligands for E3 Ligase
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/e3-ligase-ligand-24.html
Solubility
10 mM in DMSO
Smiles
CC1=C(C(N2CCC(C(NC)=O)CC2)=O)OC(S(=O)(NC3=C(NC=C4Cl)C4=C(Cl)C=C3)=O)=C1
Molecular Formula
C21H22Cl2N4O5S
Molecular Weight
513.39
References & Citations
[1]Lucas SCC, et al. Optimization of Potent Ligands for the E3 Ligase DCAF15 and Evaluation of Their Use in Heterobifunctional Degraders. J Med Chem. 2024 Apr 11;67 (7) :5538-5566.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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