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E3 ligase Ligand 24

E3 ligase Ligand 24 (Compound 24) is a Potent Ligand for the E3 Ligase DCAF15 (IC50= 0.053 μM) . Due to E3 ligase Ligand 24’s selectivity and potent binding characteristics, it is pivotal in the study of targeted protein degradation[1].

Product Specifications

CAS Number

3038773-47-3

UNSPSC

12352005

Target

Ligands for E3 Ligase

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/e3-ligase-ligand-24.html

Solubility

10 mM in DMSO

Smiles

CC1=C(C(N2CCC(C(NC)=O)CC2)=O)OC(S(=O)(NC3=C(NC=C4Cl)C4=C(Cl)C=C3)=O)=C1

Molecular Formula

C21H22Cl2N4O5S

Molecular Weight

513.39

References & Citations

[1]Lucas SCC, et al. Optimization of Potent Ligands for the E3 Ligase DCAF15 and Evaluation of Their Use in Heterobifunctional Degraders. J Med Chem. 2024 Apr 11;67 (7) :5538-5566.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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