What is the catalog number for TAK-683?

The catalog number for TAK-683 is HY-P2161.

What sizes are available for TAK-683?

TAK-683 is available in the following size(s): 1 Each.

TAK-683 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures TAK-683?

TAK-683 is manufactured by QuantiMol.

What is the estimated delivery time for TAK-683?

Estimated delivery time for TAK-683 is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for TAK-683?

The safety data sheet for TAK-683 is available here: http://file.medchemexpress.com/batch_PDF/HY-P2161/.

TAK-683

TAK-683 is a potent full KISS1 receptor (KISS1R) agonist (IC50=170 pM) with improved metabolic stability. TAK-683 is a nonapeptide metastin analog, exhibits agonistic activities to KISS1R with EC50 values of 0.96 nM and 1.6 nM for human and rat, respectively[1]. TAK-683 depletes GnRH in the hypothalamus and reduces plasma FSH, LH, and testosterone levels in vivo, it has the potential for the study of hormone-dependent prostate cancer[1][2][4].

Product Specifications

CAS Number

872719-49-8

UNSPSC

12352209

Target

Kisspeptin Receptor

Type

Peptides

Related Pathways

GPCR/G Protein

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tak-683.html

Solubility

10 mM in DMSO

Smiles

O=C(N)[C@H](CC1=CNC2=C1C=CC=C2)NC([C@H](CCCNC(NC)=N)NC([C@H](CC(C)C)NC(NNC([C@H](CC3=CC=CC=C3)NC([C@H]([C@H](O)C)NC([C@H](CC(N)=O)NC([C@@H](CC4=CNC5=C4C=CC=C5)NC([C@@H](CC6=CC=C(O)C=C6)NC(C)=O)=O)=O)=O)=O)=O)=O)=O)=O

Molecular Formula

C64H83N17O13

Molecular Weight

1298.45

References & Citations

[1]Asami T, et al.Design, synthesis, and biological evaluation of novel investigational nonapeptide KISS1R agonists with testosterone-suppressive activity.J Med Chem. 2013 Nov 14;56 (21) :8298-307.|[2]Nishizawa N, et al. Design and Synthesis of an Investigational Nonapeptide KISS1 Receptor (KISS1R) Agonist, Ac-d-Tyr-Hydroxyproline (Hyp) -Asn-Thr-Phe-azaGly-Leu-Arg (Me) -Trp-NH2 (TAK-448), with Highly Potent Testosterone-Suppressive Activity and Excellent Water Solubility. J Med Chem. 2016 Oct 13;59 (19) :8804-8811. Epub 2016 Sep 21.|[3]Matsui H, et al. Pharmacologic profiles of investigational kisspeptin/metastin analogues, TAK-448 and TAK-683, in adult male rats in comparison to the GnRH analogue leuprolide.Eur J Pharmacol. 2014 Jul 15;735:77-85.|[4]Hisanori MATSUI, et al. Functional Analyses of Kisspeptin in Controlling Gonadal Functions