Leupeptin

<strong>Leupeptin</strong> <strong>Catalog number:</strong> MDP0391 <strong>CAS Number: </strong>98897-20-2 <strong>Sequence: </strong>Acetyl-L-leucyl-L-leucyl-L-argininal hemisulfate monohydrate <strong>Amount:</strong> 10 mg <strong>Molecular Weight:</strong> 426.4 g/mol <strong>Supplied as:</strong> Powder <strong>Applications:</strong> molecular tool for various biochemical applications <strong>Storage:</strong> -20 °C <strong>WARNING:</strong> For in vitro Research Use Only. NOT for use on humans or animals. <strong>Grade:</strong> Biotechnology grade. All products are highly pure. <strong>References:</strong> 1: Gurevich M, Iocolano K, Martin IN, Singh G, Khan SU, Bui DT, Dagum AB, Komatsu DE. Efficacy of leupeptin in treating ischemia in a rat hind limb model Physiol Rep. 2022 Aug;10(15):e15411. 2: Li JH, Oh J, Kienesberger S, Kim NY, Clarke DJ, Zechner EL, Crawford JM. Making and Breaking Leupeptin Protease Inhibitors in Pathogenic Gammaproteobacteria Angew Chem Int Ed Engl. 2020 Oct 5;59(41):17872-17880. 3: Billinger E, Viljanen J, Lind SB, Johansson G. Inhibition properties of free and conjugated leupeptin analogues FEBS Open Bio. 2020 Dec;10(12):2605-2615. 4: Fu L, Shao S, Feng Y, Ye F, Sun X, Wang Q, Yu F, Wang Q, Huang B, Niu P, Li X, Wong CCL, Qi J, Tan W, Gao GF. Mechanism of Microbial Metabolite Leupeptin in the Treatment of COVID-19 by Traditional Chinese Medicine Herbs mBio. 2021 Oct 26;12(5):e0222021. 5: Ramakrishnan J, Kandasamy S, Iruthayaraj A, Magudeeswaran S, Chinnasamy K, Poomani K. Strong Binding of Leupeptin with TMPRSS2 Protease May Be an Alternative to Camostat and Nafamostat for SARS-CoV-2 Repurposed Drug: Evaluation from Molecular Docking and Molecular Dynamics Simulations Appl Biochem Biotechnol. 2021 Jun;193(6):1909-1923. 6: Suzukake K, Takada M, Hori M, Umezawa H. Biosynthesis of leupeptin. IV. Is protein turnover in leupeptin producer cells affected by leupeptin? J Antibiot (Tokyo). 1980 Oct;33(10):1172-6. 7: Hashimoto Y. Gelatin Zymography Using Leupeptin for the Detection of Various Cathepsin L Forms Methods Mol Biol. 2017;1594:243-254. 8: McConnell RM, Barnes GE, Hoyng CF, Gunn JM. New leupeptin analogues: synthesis and inhibition data J Med Chem. 1990 Jan;33(1):86-93. 9: Veeraragavan K, Gagnon C. Leupeptin and chymostatin inhibit mammalian protein methylesterase activity Biochem Biophys Res Commun. 1987 Jan 30;142(2):603-8. <a href="https://pubmed.ncbi.nlm.nih.gov/2056777">10: Ivy GO, Kanai S, Ohta M, Sato Y, Otsubo K, Kitani K. Leupeptin causes an accumulation of lipofuscin-like substances in liver cells of young rats Mech Ageing Dev. 1991 Mar;57(3):213-31. </a> <br><strong>Products Related to Leupeptin can be found at</strong> <a href="https://moleculardepot.com/product-category/Peptides/"> Peptides</a>