HbF inducer 2
HbF inducer 3 (Compound dWIZ-2) is an orally active molecular glue, which degrades the WIZ transcription factor (DC50=13 nM in primary human erythroid precursor cell) and induces the expression of fetal hemoglobin (HbF) (EC50=100 nM) . HbF inducer 3 exhibits good pharmacokinetic characteristics in cynomolgus monkeys[1].
Product Specifications
CAS Number
[2654011-51-3]
UNSPSC
12352005
Target
Histone Acetyltransferase; Molecular Glues
Type
Reference compound
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/hbf-inducer-2.html
Concentration
10mM
Purity
99.38
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C(N(CC1=C2C=CC(OC[C@@H]3N(CC)CCCC3)=C1)C2=O)CC4)NC4=O
Molecular Formula
C21H27N3O4
Molecular Weight
385.46
References & Citations
[1]Ting PY, et al., A molecular glue degrader of the WIZ transcription factor for fetal hemoglobin induction. Science. 2024 Jul 5;385 (6704) :91-99.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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