(S) -BMS-378806
(S) -BMS-378806 ((S) -BMS-806) is an orally bioavailable HIV-1 inhibitor with activity against gp120-CD4 interactions. (S) -BMS-378806 exhibits micromolar inhibition of HIV-1 gp120-CD4 binding. The design and synthesis of (S) -BMS-378806 was based on a comprehensive study of protein-ligand interactions, which guided the identification and design of novel symmetrical N, N'-disubstituted aminoureas and thioureas. (S) -BMS-378806, synthesized in aqueous media using microwave irradiation, was validated for its inhibitory activity in HIV-1 gp120-CD4 capture ELISA[1].
Product Specifications
CAS Number
357263-14-0
Product Name Alternative
(S) -BMS-806
UNSPSC
12352005
Target
HIV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/s-bms-378806.html
Smiles
C[C@@H]1N(CCN(C1)C(C2=CC=CC=C2)=O)C(C(C3=CNC4=NC=CC(OC)=C43)=O)=O
Molecular Formula
C22H22N4O4
Molecular Weight
406.43
References & Citations
[1]Molecular docking guided structure based design of symmetrical N, N'-disubstituted urea/thiourea as HIV-1 gp120-CD4 binding inhibitors
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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