Odetiglucan

Odetiglucan is a novel β-glucan that is a potent immunostimulant and a Dectin-1 (CLEC7A) agonist. Odetiglucan activates innate immune effector cells and triggers a coordinated anti-cancer immune response[1][2].

Product Specifications

CAS Number

[53238-80-5]

Product Name Alternative

BTH 1677; Imprime PGG

UNSPSC

12352211

Hazard Statement

H315, H319, H335

Target

Toll-like Receptor (TLR)

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/odetiglucan.html

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 100 mg/mL (ultrasonic)

Smiles

OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3[C@H](O)[C@@H](O[H])[C@H](O)[C@@H](CO)O3)[C@H](O)[C@@H](CC[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O[H])[C@H]4O)O2)[C@@H]1O.[x].[y].[x=y~10;z~4;n~4;(x+y+z+1)xn~100].[(C6H10O5)n(H2O);n=100;M=16kDa].[z]

Precautions

H315, H319, H335

References & Citations

[1]WHO Drug Information. International Nonproprietary Names for Pharmaceutical|[2]Stacy K Thomas, et al. Kupffer cells prevent pancreatic ductal adenocarcinoma metastasis to the liver in mice. Nat Commun. 2023 Oct 10;14 (1) :6330.