(S) -Seco-Duocarmycin SA
(S) -Seco-Duocarmycin SA is the S-enantiomer of Seco-Duocarmycin SA. Seco-Duocarmycin SA is a DNA alkylating agent. Seco-Duocarmycin SA is an antitumor antibiotic (IC50 = 10 pM). Seco-Duocarmycin SA can induce a concentration-dependent increase in apoptotic cell death. Seco-Duocarmycin SA can lead to significant cell cycle arrest in S and G2/M phases. Seco-Duocarmycin SA acts as an ADC cytotoxin for antibody-drug conjugates[1][2][3].
Product Specifications
CAS Number
152785-82-5
UNSPSC
12352203
Target
ADC Payload; Antibiotic; Apoptosis; DNA Alkylator/Crosslinker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; Anti-infection; Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/s-seco-duocarmycin-sa.html
Purity
99.0
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
ClC[C@H]1C2=C(C=C(O)C3=C2C=C(C(OC)=O)N3)N(C(C4=CC5=CC(OC)=C(OC)C(OC)=C5N4)=O)C1
Molecular Formula
C25H24ClN3O7
Molecular Weight
513.93
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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