(S) -Seco-Duocarmycin SA

(S) -Seco-Duocarmycin SA is the S-enantiomer of Seco-Duocarmycin SA (HY-129356) . Seco-Duocarmycin SA is a DNA alkylating agent. Seco-Duocarmycin SA is an antitumor antibiotic (IC50 = 10 pM) . Seco-Duocarmycin SA can induce a concentration-dependent increase in apoptotic cell death. Seco-Duocarmycin SA can lead to significant cell cycle arrest in S and G2/M phases. Seco-Duocarmycin SA acts as an ADC cytotoxin for antibody-drug conjugates[1][2][3].

Product Specifications

CAS Number

[152785-82-5]

UNSPSC

12352203

Target

ADC Payload; Antibiotic; Apoptosis; DNA Alkylator/Crosslinker

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related; Anti-infection; Apoptosis; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/s-seco-duocarmycin-sa.html

Purity

99.0

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

ClC[C@H]1C2=C(C=C(O)C3=C2C=C(C(OC)=O)N3)N(C(C4=CC5=CC(OC)=C(OC)C(OC)=C5N4)=O)C1

Molecular Formula

C25H24ClN3O7

Molecular Weight

513.93

References & Citations

[1]Tichenor MS, et al. Systematic exploration of the structural features of yatakemycin impacting DNA alkylation and biological activity. J Am Chem Soc. 2007 Sep 5;129 (35) :10858-69.|[2]Morcos, A., et al., (2025) . Seco-Duocarmycin SA in Aggressive Glioblastoma Cell Lines. International journal of molecular sciences, 26 (6), 2766.|[3]Lutz F. Tietze, et al. A Concise and Efficient Synthesis of seco-Duocarmycin SA. European Journal of Organic Chemistry 2003 (3), 562-566.