Astin B

Astin B is a orally active and potent cyclic pentapeptide, that can be isolated from Aster tataricus. Astin B has hepatotoxic effects in vitro and in vivo and that hepatic injury was primarily mediated by apoptosis in a mitochondria/caspase-dependent manner. Astin B induces autophagy in L-02 cells, increases LC3-II and decreases p62 expression[1].

Product Specifications

CAS Number

[151201-76-2]

UNSPSC

12352209

Target

Apoptosis; Atg8/LC3; Autophagy; Bcl-2 Family; Caspase; JNK; p62; Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Apoptosis; Autophagy; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/astin-b.html

Solubility

H2O

Smiles

Cl[C@H](C1)[C@@H](Cl)[C@@](N1C([C@H](CC)NC(C[C@H](C2=CC=CC=C2)N3)=O)=O)([H])C(N[C@H]([C@H](C)O)C(N[C@@H](CO)C3=O)=O)=O

Molecular Formula

C25H33Cl2N5O7

Molecular Weight

586.46

References & Citations

[1]Wang L, et al. Astin B, a cyclic pentapeptide from Aster tataricus, induces apoptosis and autophagy in human hepatic L-02 cells. Chem Biol Interact. 2014 Nov 5;223:1-9.