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Toremifene (citrate) (Standard)

Toremifene (citrate) (Standard) is the analytical standard of Toremifene (citrate) . This product is intended for research and analytical applications. Toremifene citrate (Z-Toremifene citrate) is a second-generation selective estrogen-receptor modulator (SERM) in development for the prevention of osteoporosis. Toremifene citrate also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.07 µM and 2.6 µM, respectively[1][2].

Product Specifications

CAS Number

89778-27-8

Product Name Alternative

Z-Toremifene (citrate) (Standard) ; NK 622 (Standard) ; FC-1157a (Standard)

UNSPSC

12352005

Target

Apoptosis; Estrogen Receptor/ERR; Reference Standards

Type

Reference Standards

Related Pathways

Apoptosis; Others; Vitamin D Related/Nuclear Receptor

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/toremifene-citrate-standard.html

Smiles

ClCC/C(C1=CC=CC=C1)=C(C2=CC=C(OCCN(C)C)C=C2)\C3=CC=CC=C3.O=C(CC(C(O)=O)(O)CC(O)=O)O

Molecular Formula

C32H36ClNO8

Molecular Weight

598.08

References & Citations

[1]Matthew R Smith, Selective Estrogen Receptor Modulators to Prevent Treatment-Related Osteoporosis.Rev Urol. 2005; 7 (Suppl 3) : S30-S35.|[2]Gauri J Sabnis, Luciana Macedo, Olga Goloubeva, Toremifene - Atamestane; Alone or In Combination: Predictions from the Preclinical Intratumoral Aromatase Model. J Steroid Biochem Mol Biol. 2008 January; 108 (1-2) : 1-7.|[3]Taneja SS, Morton R, Barnette G, Prostate cancer diagnosis among men with isolated high-grade intraepithelial neoplasia enrolled onto a 3-year prospective phase III clinical trial of oral toremifene. J Clin Oncol. 2013 Feb 10;31 (5) :523-9.|[4]Laura Cooper, et al. Screening and Reverse-Engineering of Estrogen Receptor Ligands as Potent Pan-Filovirus Inhibitors. J Med Chem. 2020 Sep 4.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Available Sizes

Frequently Asked Questions

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