DL-threo-Dihydrosphingosine
DL-threo-Dihydrosphingosine is a extracellular signal-regulated kinase (ERK) signalling cassette inhibitor and is effective against both growth factor- and G-protein-dependent activation of ERK. DL-threo-Dihydrosphingosine inhibits smooth muscle cell proliferation and can be used for study of asthma[1][2].
Product Specifications
CAS Number
2304-75-8
UNSPSC
12352211
Target
ERK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway; Stem Cell/Wnt
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/dl-threo-dihydrosphingosine.html
Smiles
CCCCCCCCCCCCCCC[C@H](O)[C@@H](N)CO
Molecular Formula
C18H39NO2
Molecular Weight
301.51
References & Citations
[1]Tolan D, et al. The identification of DL-threo dihydrosphingosine and sphingosine as novel inhibitors of extracellular signal-regulated kinase signalling in airway smooth muscle. Br J Pharmacol. 1996;119 (2) :185-186.|[2]Yoshida K, et al. ELOVL6 deficiency aggravates allergic airway inflammation through the ceramide-S1P pathway in mice. J Allergy Clin Immunol. 2023;151 (4) :1067-1080.e9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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