OB-1

OB-1 is a stomatin-like protein-3 (STOML3) oligomerization blocker. OB-1 is an effective inhibitor of the self-association of Stomatin, STOML1 and STOML2, but not podocin[1].

Product Specifications

CAS Number

[300803-69-4]

UNSPSC

12352005

Target

SPFH Protein Superfamily

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ob-1.html

Purity

99.12

Solubility

DMSO : 12.73 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1=C(C2=CC=CC=C2)OC3=CC=C(OC4=C([N+]([O-])=O)N=CN4C)C=C13)OCC

Molecular Formula

C21H17N3O6

Molecular Weight

407.38

References & Citations

[1]Wetzel C, et al. Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity. Nat Neurosci. 2017 Feb;20 (2) :209-218.