TP0472993
CYP4A11/CYP4F2-IN-2 is a potent and orally active dual inhibitor of cytochrome P450 (CYP) 4A11 and CYP4F2, with IC50s of 140 nM and 40 nM, respectively. CYP4A11/CYP4F2-IN-2 has potential for the research of renal diseases[1].
Product Specifications
CAS Number
2126874-77-7
UNSPSC
12352005
Target
Cytochrome P450
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/tp0472993.html
Concentration
10mM
Purity
98.22
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
CC(N1CCC(CC1)COC2=CC=C(N=C2)C3=CC=NN3)=O
Molecular Formula
C16H20N4O2
Molecular Weight
300.36
References & Citations
[1]Kawamura M, et, al. Discovery of Novel Pyrazolylpyridine Derivatives for 20-Hydroxyeicosatetraenoic Acid Synthase Inhibitors with Selective CYP4A11/4F2 Inhibition. J Med Chem. 2022 Nov 10;65 (21) :14599-14613.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CYP4
Available Sizes
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