TP0472993

CYP4A11/CYP4F2-IN-2 is a potent and orally active dual inhibitor of cytochrome P450 (CYP) 4A11 and CYP4F2, with IC50s of 140 nM and 40 nM, respectively. CYP4A11/CYP4F2-IN-2 has potential for the research of renal diseases[1].

Product Specifications

CAS Number

[2126874-77-7]

UNSPSC

12352005

Target

Cytochrome P450

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/tp0472993.html

Concentration

10mM

Purity

98.22

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

CC(N1CCC(CC1)COC2=CC=C(N=C2)C3=CC=NN3)=O

Molecular Formula

C16H20N4O2

Molecular Weight

300.36

References & Citations

[1]Kawamura M, et, al. Discovery of Novel Pyrazolylpyridine Derivatives for 20-Hydroxyeicosatetraenoic Acid Synthase Inhibitors with Selective CYP4A11/4F2 Inhibition. J Med Chem. 2022 Nov 10;65 (21) :14599-14613.