Mancozeb

Mancozeb is a widely used fungicide that is effective against fungal diseases in most cereals, vegetables, fruits and ornamental plants. In addition, Mancozeb can cause liver damage in mice by activating the Keap1/Nrf2 signaling pathway. Mancozeb upregulates lactate dehydrogenase and cytochrome c to alter cell metabolism and induce cell death. Mancozeb has reproductive toxicity and can induce apoptosis in ovarian cells[1][2][3][4].

Product Specifications

CAS Number

[8018-01-7]

UNSPSC

12352005

Hazard Statement

H317, H351, H360, H373, H410

Target

Apoptosis; Cytochrome P450; Fungal; Keap1-Nrf2; Lactate Dehydrogenase

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis; Metabolic Enzyme/Protease; NF-κB

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer; Infection; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/mancozeb.html

Purity

85.50

Solubility

DMSO : 1 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 80°C)

Smiles

S=C([S-])NCCNC1=[S][Mn]([Mn+])[S-]1.S=C([S-])NCCNC2=[S][Zn]([Zn+])[S-]2

Molecular Formula

C8H12Mn2N4S8Zn2 2-

Molecular Weight

661.36

Precautions

H317, H351, H360, H373, H410

References & Citations

[1]Santos R, er al. Thyroid and reproductive hormones in relation to pesticide use in an agricultural population in Southern Brazil. Environ Res. 2019 Jun;173:221-231.|[2]WENX Pirozzi AV, et al. Mancozeb, a fungicide routinely used in agriculture, worsens nonalcoholic fatty liver disease in the human HepG2 cell model. Toxicol Lett. 2016 May 13;249:1-4.|[3]Gao N, et al. The administration of Glycyrrhiza polysaccharides mitigates liver injury in mice caused by mancozeb via the Keap1-Nrf2/NF-κB pathway. Food Chem Toxicol. 2024 Nov 4:115088.|[4]Bao J, et al. Low level of mancozeb exposure affects ovary in mice. Ecotoxicol Environ Saf. 2022 Jul 1;239:113670.