(R) - (-) -JQ1 Enantiomer
(R) - (-) -JQ1 Enantiomer is the stereoisomer of (+) -JQ1. (+) -JQ1 potently decreases expression of both BRD4 target genes, whereas (R) - (-) -JQ1 Enantiomer has no effect.
Product Specifications
CAS Number
[1268524-71-5]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/_R_-_-_-JQ1-Enantiomer.html
Purity
99.79
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(C[C@H]1N=C(C2=C(N3C1=NN=C3C)SC(C)=C2C)C4=CC=C(C=C4)Cl)OC(C)(C)C
Molecular Formula
C23H25ClN4O2S
Molecular Weight
456.99
Precautions
H302, H315, H319, H335
References & Citations
[1]Filippakopoulos, et al. Selective inhibition of BET bromodomains. Nature. 2010 Dec 23;468 (7327) :1067-73.|[2]Mahe M, et al. An FGFR3/MYC positive feedback loop provides new opportunities for targeted therapies in bladder cancers. EMBO Mol Med. 2018 Apr;10 (4) . pii: e8163.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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