3BrB-PP1

3BrB-PP1 is an ATP-competitive analog. 3BrB-PP1 can specifically inhibit the activity of protein kinase with mutations in the ATP-binding pocket (mutation of Thr97 within Sty1’s ATP-binding pocket) [1][2].

Product Specifications

CAS Number

[956025-99-3]

Product Name Alternative

(Rac)-Rebemadlin,PF-2545920 (succinate)

UNSPSC

12352005

Target

Others

Type

Reference compound

Related Pathways

Others

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/3brb-pp1.html

Purity

99.0

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

NC1=C2C(N(C(C)(C)C)N=C2CC3=CC=CC(Br)=C3)=NC=N1

Molecular Formula

C16H18BrN5

Molecular Weight

360.25

References & Citations

[1]Tay YD, et, al. Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex. Cell Rep. 2019 Feb 5;26 (6) :1654-1667.e7.|[2]Mutavchiev DR, et, al. Remodeling of the Fission Yeast Cdc42 Cell-Polarity Module via the Sty1 p38 Stress-Activated Protein Kinase Pathway. Curr Biol. 2016 Nov 7;26 (21) :2921-2928.