Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Human GUCY2C / Guanylyl cyclase C Protein, Fc Tag (MALS verified)

GUCY2C (Guanylyl Cyclase C), also known as heat-stable enterotoxin receptor, is a type I transmembrane protein of the guanylate cyclase (gc) family that signal by producing cGMP. Guanylate cyclase C (GUCY2C) and its hormones guanylin and uroguanylin have recently emerged as one paracrine axis defending intestinal mucosal integrity against mutational, chemical, and inflammatory injury. GUCY2C murine CAR-T cells recognized and killed human colorectal cancer cells endogenously expressing GUCY2C. Thus, we have identified a human GUCY2C-specific CAR-T cell therapy approach that may be developed for the treatment of GUCY2C-expressing metastatic colorectal cancer.

Product Specifications

Background

GUCY2C (Guanylyl Cyclase C), also known as heat-stable enterotoxin receptor, is a type I transmembrane protein of the guanylate cyclase (gc) family that signal by producing cGMP. Guanylate cyclase C (GUCY2C) and its hormones guanylin and uroguanylin have recently emerged as one paracrine axis defending intestinal mucosal integrity against mutational, chemical, and inflammatory injury. GUCY2C murine CAR-T cells recognized and killed human colorectal cancer cells endogenously expressing GUCY2C. Thus, we have identified a human GUCY2C-specific CAR-T cell therapy approach that may be developed for the treatment of GUCY2C-expressing metastatic colorectal cancer.

Specifications

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 72.5 kDa. The protein migrates as 80-130 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Accession Number

P25092-1

Expression Region

Ser 24 - Gln 430

Host

HEK293

Target

GUCY2C

Conjugation

Unconjugated

Tag

C-Fc

Source

Human

Stability

-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Endotoxin

0.1 EU per μg

Purity

95%

Bioactivity

Immobilized Human GUCY2C, Fc Tag (Cat. No. GUC-H5257) at 5 μg/mL (100 μL/well) can bind Monoclonal Anti-Human GUCY2C Antibody, Human IgG1 with a linear range of 0.3-5 ng/mL (QC tested).

Format

Powder

Buffer

PBS, pH7.4

Additives

Trehalose

Molecular Weight

72.5 kDa

Additionnal Information

Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/support/shipping-and-payments

Shipping Conditions

RT

Storage Conditions

-20°C

Package Size

500ug*2

Product Datasheet

https://console.acrobiosystems.com/public/product/pdf/ds/GUC-H5257.pdf

Host or Source

HEK293

Species

Human

Protein ID

P25092-1

Preservative

Trehalose

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

GAGE2A, 1-116aa, Human, His tag, E Coli
MBS204832-01 0.02 mg

GAGE2A, 1-116aa, Human, His tag, E Coli

Ask
View Details
GAGE2A, 1-116aa, Human, His tag, E Coli
MBS204832-02 0.1 mg

GAGE2A, 1-116aa, Human, His tag, E Coli

Ask
View Details
GAGE2A, 1-116aa, Human, His tag, E Coli
MBS204832-03 5x 0.02 mg

GAGE2A, 1-116aa, Human, His tag, E Coli

Ask
View Details
GAGE2A, 1-116aa, Human, His tag, E Coli
MBS204832-04 0.5 mg

GAGE2A, 1-116aa, Human, His tag, E Coli

Ask
View Details
GAGE2A, 1-116aa, Human, His tag, E Coli
MBS204832-05 5x 0.1 mg

GAGE2A, 1-116aa, Human, His tag, E Coli

Ask
View Details
GAGE2A, 1-116aa, Human, His tag, E Coli
MBS204832-06 5x 0.5 mg

GAGE2A, 1-116aa, Human, His tag, E Coli

Ask
View Details