5-Hydroxy-TSU-68

5-Hydroxy-TSU-68 (compound M1) is the 5-hydroxylated indolinone derivative of TSU-68. TSU-68 is an anticancer agent that inhibits angiogenic receptor tyrosine kinases[1].

Product Specifications

CAS Number

[1035154-46-1]

UNSPSC

12352005

Target

Endogenous Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/5-hydroxy-tsu-68.html

Solubility

10 mM in DMSO

Smiles

O=C(O)CCC1=C(C)NC(/C=C2C(NC3=C\2C=C(O)C=C3)=O)=C1C

Molecular Formula

C18H18N2O4

Molecular Weight

326.35

References & Citations

[1]Kitamura R, et, al. Identification of Human Liver Cytochrome P450 Isoforms Involved in Autoinduced Metabolism of the Antiangiogenic Agent (Z) -5-[ (1,2-Dihydro-2-oxo-3H-indol-3-ylidene) methyl]-2,4-dimethyl-1H-pyrrole-3-propanoic Acid (TSU-68) . Drug Metabolism and Disposition June 2008, 36 (6) 1003-1009.