Reparixin (L-lysine salt)

[1]Moriconi A, et al. Design of noncompetitive interleukin-8 inhibitors acting on CXCR1 and CXCR2. J Med Chem. 2007 Aug 23;50 (17) :3984-4002.|[2]Bertini R, et al. Receptor binding mode and pharmacological characterization of a potent and selective dual CXCR1/CXCR2non-competitive allosteric inhibitor. Br J Pharmacol. 2012 Jan;165 (2) :436-54.|[3]Midgley I, et al. Species differences in the pharmacokinetics and metabolism of reparixin in rat and dog. Xenobiotica. 2006 May;36 (5) :419-40|[4]Catrina, Anca, et al. METHODS AND COMPOUNDS FOR THE TREATMENT OF BONE LOSS AND/OR PAIN. US 20170105971 A1.|[5]Bertini R, et al. Noncompetitive allosteric inhibitors of the inflammatory chemokine receptors CXCR1 and CXCR2: prevention of reperfusion injury. Proc Natl Acad Sci U S A. 2004 Aug 10;101 (32) :11791-6.

Ann Rheum Dis. 2016 Apr;75 (4) :721-9.|Biomed Res Int. 2020 Aug 5;2020:4670604.|bioRxiv. 2020 Sep 12:2020.08.25.265561.|Neurobiol Dis. 2021 Dec:160:105538.|Patent. US20170105971A1.|Patent. US20170181987A1.|Patent. US20240295544A1.|Adv Sci (Weinh) . 2024 Sep 13:e2403430.|Adv Sci (Weinh) . 2025 Jan 30:e2406218.|Ann Rheum Dis. 2016 Apr;75 (4) :730-8.|Biochim Biophys Acta. 2017 Jan;1863 (1) :220-230.|bioRxiv. 2024 Jun 6:2024.01.30.577927.|bioRxiv. 2025 Mar 19:2025.03.19.644113.|bioRxiv. 2025 Sep 3:2025.09.02.672566.|BMC Med. 2022 Feb 8;20 (1) :55.|Brain Pathol. 2024 Jun 30:e13283.|Brain Res Bull. 2025 Oct 22:232:111594.|Cancer Cell Int. 2021 Jul 3;21 (1) :337.|Cancer Cell. 2023 Apr 10;41 (4) :693-710.e8.|Cancers (Basel) . 2023 Sep 4;15 (17) :4422.|Cell Biosci. 2019 Jan 3:9:4.|Cell Commun Signal. 2023 Mar 13;21 (1) :59.|Cell Death Dis. 2017 Jul 13;8 (7) :e2932.|Cell Mol Gastroenterol Hepatol. 2024 May 7:S2352-345X (24) 00105-X.|Cells. 2022 Aug 4;11 (15) :2402.|Cells. 2022 Jun 21;11 (13) :1986.|EBioMedicine. 2019 May:43:487-500.|FACETS. 2020 Jul.|Front Immunol. 2018 Sep 12:9:2058.|Front Immunol. 2021 May 7;12:667177.|Front Immunol. 2022 Oct 17:13:1007341.|Gene. 2018 Nov 30:677:149-162.|Int J Biol Sci. 2022 Jan 16;18 (4) :1363-1380.|J Allergy Clin Immunol. 2018 Jun;141 (6) :2286-2289.e5.|J Biomed Sci. 2025 Jan 6;32 (1) :5.|J Cell Mol Med. 2020 Jan;24 (2) :1588-1598.|J Cell Mol Med. 2020 Nov;24 (21) :12608-12618.|J Gastroenterol Hepatol. 2018 Feb;33 (2) :431-442.|J Immunol. 2018 Jul 15;201 (2) :814-820. |J Mol Cell Biol. 2023 Aug 3;15 (4) :mjad025.|J Mol Med (Berl) . 2019 Jan;97 (1) :25-35. |Johns Hopkins University. Department of Chemical and Biomolecular Engineering. 2016 Dec.|Karolinska Institutet. Dept of Physiology and Pharmacology. 2022 Feb.|Mol Biomed. 2025 Jun 10;6 (1) :40.|Mol Immunol. 2018 Sep:101:440-449.|Mol Ther. 2022 Nov 2;30 (11) :3430-3449.|Nat Commun. 2017 May 26;8:15584.|Oncogenesis. 2016 Jun 13;5 (6) :e234. |Oncotarget. 2017 Jul 21;8 (36) :60210-60222.|Oncotarget. 2018 Aug 24;9 (66) :32556-32569. |Patent. US20220251222A1.|Research Square Preprint. 2021 Mar.|Sci Adv. 2019 May 8;5 (5) :eaav7384.|Sci Rep. 2017 Nov 6;7 (1) :14510. |Stem Cells. 2015 Dec;33 (12) :3558-68. |University of Michigan. 2018 Oct.|Vet Immunol Immunopathol. 2016 Dec:182:52-58.|Xenotransplantation. 2018 Mar;25 (2) :e12385.