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FKBP12 PROTAC dTAG-7

FKBP12 PROTAC dTAG-7 (dTAG-7) is a heterobifunctional PROTAC degrader. FKBP12 PROTAC dTAG-7 targets FKBP12F36V and BET BRD4. FKBP12 PROTAC dTAG-7 enables rapid and selective degradation of target proteins, and is suitable for cellular and in vivo studies to analyze protein functions and validate targets[1]. (Pink: target protein ligand (HY-114420) ; Black: linker (HY-128844) ; Blue: CRBN Ligand (HY-103597) ; CRBN Ligand+linker: (HY-W722323) )

Product Specifications

CAS Number

[2064175-32-0]

Product Name Alternative

DTAG-7

UNSPSC

12352005

Target

Epigenetic Reader Domain; FKBP; PROTACs

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/fkbp12-protac-dtag-7.html

Purity

99.88

Solubility

DMSO : 100 mg/mL

Smiles

O=C([C@H]1N(C([C@H](C2=CC(OC)=C(OC)C(OC)=C2)CC)=O)CCCC1)O[C@@H](C3=CC=CC=C3OCC(NCCCOCCOCCOCCCNC(COC4=CC=CC(C(N5C(CC6)C(NC6=O)=O)=O)=C4C5=O)=O)=O)CCC7=CC=C(OC)C(OC)=C7

Molecular Formula

C63H79N5O19

Molecular Weight

1210.32

References & Citations

[1]Nabet B, et al. The dTAG system for immediate and target-specific protein degradation. Nat Chem Biol. 2018 May;14 (5) :431-441.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

BRD4; Cereblon; FKBP12

Available Sizes

Curated Selection

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