CAPN2, Human (His)

CAPN2 (Calpain-2) is a calcium-regulated, non-lysosomal thiol protease known for catalyzing the limited proteolysis of substrates critical for cytoskeletal remodeling and signaling. Notably, CAPN2 proteolytically cleaves MYOC at “Arg-226,” suggesting its involvement in regulating the function of this protein. CAPN2 Protein, Human (His) is the recombinant human-derived CAPN2 protein, expressed by E. coli , with N-6*His labeled tag. The total length of CAPN2 Protein, Human (His) is 681 a.a., with molecular weight of ~82.1 kDa.

SHDRAIKYLN QDYEALRNEC LEAGTLFQDP SFPAIPSALG FKELGPYSSK TRGIEWKRPT EICADPQFII GGATRTDICQ GALGDCWLLA AIASLTLNEE ILARVVPLNQ SFQENYAGIF HFQFWQYGEW VEVVVDDRLP TKDGELLFVH SAEGSEFWSA LLEKAYAKIN GCYEALSGGA TTEGFEDFTG GIAEWYELKK PPPNLFKIIQ KALQKGSLLG CSIDITSAAD SEAITFQKLV KGHAYSVTGA EEVESNGSLQ KLIRIRNPWG EVEWTGRWND NCPSWNTIDP EERERLTRRH EDGEFWMSFS DFLRHYSRLE ICNLTPDTLT SDTYKKWKLT KMDGNWRRGS TAGGCRNYPN TFWMNPQYLI KLEEEDEDEE DGESGCTFLV GLIQKHRRRQ RKMGEDMHTI GFGIYEVPEE LSGQTNIHLS KNFFLTNRAR ERSDTFINLR EVLNRFKLPP GEYILVPSTF EPNKDGDFCI RVFSEKKADY QAVDDEIEAN LEEFDISEDD IDDGFRRLFA QLAGEDAEIS AFELQTILRR VLAKRQDIKS DGFSIETCKI MVDMLDSDGS GKLGLKEFYI LWTKIQKYQK IYREIDVDRS GTMNSYEMRK ALEEAGFKMP CQLHQVIVAR FADDQLIIDF DNFVRCLVRL ETLFKIFKQL DPENTGTIEL DLISWLCFSV L