PFI-7
PFI-7 is a probe, which binds to human GID4 (KD is 79 nM), and antagonizes the binding of Pro/N-degrons. PFI-7 can be utilized in C-terminal to LisH (CTLH) complex research and development of targeted protein degradation[1].
Product Specifications
CAS Number
[2910938-58-6]
UNSPSC
12171500
Target
E1/E2/E3 Enzyme
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/pfi-7.html
Smiles
O=C(N[C@@H]1CC[C@H](C2=NC(C=CC=C3)=C3N2)CC1)CNCC4=CC5=C(C=CC=C5)N4
Molecular Formula
C24H27N5O
Molecular Weight
401.50
References & Citations
[1]Owens DDG, et al., A chemical probe to modulate human GID4 Pro/N-degron interactions. Nat Chem Biol. 2024 May 21.
Shipping Conditions
Room temperature
Scientific Category
Dye Reagents
Clinical Information
No Development Reported
Curated Selection
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