Pyr6

Pyr6 is a selective store operated calcium entry (SOCE) inhibitor with an IC50 of 0.49 μM. Pyr6 displays 37-fold higher potency for RBL SOCE than for TRPC3 ROCE[1].

Product Specifications

CAS Number

[245747-08-4]

Product Name Alternative

N-[4-[3,5-Bis (trifluoromethyl) -1H-pyrazol-1-yl]phenyl]-3-fluoro-4-pyridinecarboxamide

UNSPSC

12352005

Hazard Statement

H302-H315-H319

Target

CRAC Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/Pyr6.html

Purity

98.61

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C(C1=C(F)C=NC=C1)NC2=CC=C(N3N=C(C(F)(F)F)C=C3C(F)(F)F)C=C2

Molecular Formula

C17H9F7N4O

Molecular Weight

418.27

Precautions

P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501

References & Citations

[1]Schleifer H, et al. Novel pyrazole compounds for pharmacological discrimination between receptor-operated and store-operated Ca (2+) entry pathways. Br J Pharmacol. 2012 Dec;167 (8) :1712-22.