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5,8-Epidioxyergosta-6,9 (11),22-trien-3-ol

Selected Variant

HY-N7175-01

Size: 1 mg

5,8-Epidioxyergosta-6,9 (11),22-trien-3-ol (9,11-Dehydroergosterol peroxide), an important steroid from medicinal mushroom, exerts antitumor activity in several tumor types. 5,8-Epidioxyergosta-6,9 (11),22-trien-3-ol inhibits HT29 cell growth by inducing CDKN1A expression, thus causing cell cycle arrest and apoptosis[1][2].

Product Specifications

CAS Number

86363-50-0

Product Name Alternative

9,11-Dehydroergosterol peroxide; 9 (11) -DHEP

UNSPSC

12352005

Target

Apoptosis; Endogenous Metabolite

Type

Natural Products

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/5-8-epidioxyergosta-6-9-11-22-trien-3-ol.html

Solubility

10 mM in DMSO

Smiles

C[C@@]1(CC[C@@H]2O)C([C@]3(C=C[C@]1(C2)OO3)[C@]4([H])CC[C@]5([H])[C@H](C)/C=C/[C@H](C)C(C)C)=CC[C@@]45C

Molecular Formula

C28H42O3

Molecular Weight

426.63

References & Citations

[1]Kobori M, Yoshida M, Ohnishi-Kameyama M, Takei T, Shinmoto H. 5alpha,8alpha-Epidioxy-22E-ergosta-6,9 (11),22-trien-3beta-ol from an edible mushroom suppresses growth of HL60 leukemia and HT29 colon adenocarcinoma cells. Biol Pharm Bull. 2006;29 (4) :755-759. |[2]Zheng L, et al. Apoptosis induced by 9,11 dehydroergosterol peroxide from Ganoderma Lucidum mycelium in human malignant melanoma cells is Mcl 1 dependent. Mol Med Rep. 2018;18 (1) :938-944.

Shipping Conditions

Room temperature

Scientific Category

Natural Products

Clinical Information

No Development Reported

Isoform

Microbial Metabolite

Available Sizes

Price

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