Selnoflast
Product Specifications
Product Name Alternative
Somalix; RO-7486967; IZD334
UNSPSC Description
Selnoflast (RO7486967), formerly somalix/RG6418/IZD334, is an orally active, potent, selective and reversible small molecule NLRP3 inflammasome inhibitor. Selnoflast is a potent inhibitor of IL-1β release stimulated by NLRP3 activation in human Alzheimer's disease (AD) monocyte-derived macrophages. Selnoflast is promising for research of AD and systemic inflammatory diseases, such as ulcerative colitis and chronic obstructive pulmonary disease[1][2][3][4][5]
Target Antigen
Interleukin Related; NOD-like Receptor (NLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/selnoflast.html
Purity
99.46
Solubility
1M NaOH : 3.33 mg/mL (adjust pH to 12 with 1M NaOH)|DMSO : 5 mg/mL (ultrasonic;adjust pH to 8 with 1M NaOH)
Smiles
O=C(NS(=O)(C1CCN(CC1)CC)=O)NC2=C(CCC3)C3=CC4=C2CCC4
Molecular Weight
391.53
References & Citations
[1]Vande Walle L, et al. Drugging the NLRP3 inflammasome: from signalling mechanisms to therapeutic targets. Nat Rev Drug Discov. 2023 Nov 29.|[2]Klughammer B, et al. A randomized, double-blind phase 1b study evaluating the safety, tolerability, pharmacokinetics and pharmacodynamics of the NLRP3 inhibitor selnoflast in patients with moderate to severe active ulcerative colitis. Clin Transl Med. 2023 Nov;13(11):e1471. |[3]McManus RM, et al. NLRP3 inflammasome signalling in Alzheimer's disease[J]. Neuropharmacology. 2024 Jul 1;252:109941. |[4]Teske KA, et al. Interrogating direct NLRP3 engagement and functional inflammasome inhibition using cellular assays[J]. Cell Chem Biol. 2024 Feb 15;31(2):349-360.e6. |[5]Zhang L, et al. Role of NLRP3 inflammasome in central nervous system diseases[J]. Cell Biosci. 2024 Jun 7;14(1):75.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-132831/Selnoflast-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-132831/Selnoflast-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2260969-36-4
Available Sizes
Curated Selection
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