Phorbol 12,13-dibutyrate

Phorbol 12,13-dibutyrate (Phorbol dibutyrate) is a PKC activator and a potent skin tumor promoter[1][2].

Product Specifications

CAS Number

[37558-16-0]

Product Name Alternative

Phorbol dibutyrate; PDBu

UNSPSC

12352211

Hazard Statement

H300+H310+H330, H314, H317, H351

Target

PKC

Type

Reference compound

Related Pathways

Epigenetics; TGF-beta/Smad

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/phorbol-12-13-dibutyrate.html

Purity

99.77

Solubility

DMSO : ≥ 125 mg/mL

Smiles

O=C1C(C)=C[C@@]2([H])[C@]3(O)[C@@]([C@@](C4(C)C)([H])[C@@]4(OC(CCC)=O)[C@H](OC(CCC)=O)[C@H]3C)([H])C=C(CO)C[C@]12O

Molecular Formula

C28H40O8

Molecular Weight

504.61

Precautions

H300+H310+H330, H314, H317, H351

References & Citations

[1]Singh J, et al. Immunocytochemical evidence for PDBu-induced activation of RhoA/ROCK in human internal anal sphincter smooth muscle cells. Am J Physiol Gastrointest Liver Physiol. 2011 Aug;301 (2) :G317-25.|[2]Szallasi Z, et al. Dissociation of phorbol esters leads to immediate redistribution to the cytosol of protein kinases C alpha and C delta in mouse keratinocytes. J Biol Chem. 1994 Nov 4;269 (44) :27159-62.|[3]Middleton JP, et al. Heterogeneity of protein kinase C-mediated rapid regulation of Na/K-ATPase in kidney epithelial cells. J Biol Chem. 1993 Jul 25;268 (21) :15958-64.