AMG 517

AMG 517 is a potent and selective vanilloid receptor-1 (TRPV1) antagonist with an IC50 of 0.5 nM.

Product Specifications

CAS Number

[659730-32-2]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

TRP Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/AMG-517.html

Purity

99.24

Solubility

DMSO : 41.67 mg/mL (ultrasonic)

Smiles

CC(NC1=NC2=C(OC3=NC=NC(C4=CC=C(C(F)(F)F)C=C4)=C3)C=CC=C2S1)=O

Molecular Formula

C20H13F3N4O2S

Molecular Weight

430.40

Precautions

H302, H315, H319, H335

References & Citations

[1]Doherty EM, et al. Novel vanilloid receptor-1 antagonists: 2. Structure-activity relationships of 4-oxopyrimidines leading to the selection of a clinical candidate. J Med Chem. 2007 Jul 26;50 (15) :3515-27.|[2]Gavva NR, et al. Repeated administration of vanilloid receptor TRPV1 antagonists attenuates hyperthermia elicited by TRPV1 blockade. J Pharmacol Exp Ther. 2007 Oct;323 (1) :128-37.