CaMKII-IN-1
CaMKII-IN-1 is a highly selective inhibitor of CaMKII with an IC50 value of 63nM. It has almost no effect on CaMKIV, MLCK, p38a, Akt1, and PKC.
Product Specifications
CAS Number
[1208123-85-6]
UNSPSC
12352005
Target
CaMK
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/CaMKII-IN-1.html
Purity
98.63
Solubility
DMSO : ≥ 54 mg/mL
Smiles
O=S(C1=CC=CC(Cl)=C1C)(NC2=C(CN(CC3=CC=CC=C3)CC4)C4=NC(NCCC5=CC=CC=C5)=N2)=O
Molecular Formula
C29H30ClN5O2S
Molecular Weight
548.10
References & Citations
[1]Asano S, et al. 5,6,7,8-Tetrahydropyrido[4,3-d]pyrimidines as novel class of potent and highly selective CaMKII inhibitors. Bioorg Med Chem Lett. 2010 Nov 15;20 (22) :6696-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CaMK II
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
247449-ML650 100 µL
IFNA2 (Interferon, alpha 2, IFNA, INFA2, MGC125764, MGC125765) (MaxLight 650)
Ask
View Details 
MBS6387145-01 0.1 mL
NME1 (NDPKA, NM23, Nucleoside Diphosphate Kinase A, NDK A, NDP Kinase A, Granzyme A-activated DNase, GAAD, Metastasis Inhibition Factor nm23, Tumor Metastatic Process-associated Protein, nm23-H1) (MaxLight 490)
Ask
View Details MBS6387145-02 5x 0.1 mL
NME1 (NDPKA, NM23, Nucleoside Diphosphate Kinase A, NDK A, NDP Kinase A, Granzyme A-activated DNase, GAAD, Metastasis Inhibition Factor nm23, Tumor Metastatic Process-associated Protein, nm23-H1) (MaxLight 490)
Ask
View Details